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The Penobscot River Synthesis began in 2005 as a literature review and data inventory of past and current research in the Penobscot River and its watershed. Anticipating increased interest in the river as the Penobscot River Restoration Project moves forward, the project aims to provide scientists, educators, and communities with needed information on Penobscot River ecology and environmental history. Initially funded by the U.S. Geological Survey Water Resources Research Institutes program and the Atlantic Salmon Federation, the synthesis project is continuing to compile and disseminate Penobscot River information.

The Senator George J. Mitchell Center for Environmental and Watershed Research has partnered with the Penobscot River Restoration Trust and the Maine Department of Environmental Protection to coordinate the Penobscot River Science Steering Committee. The committee is responsible for overseeing scientific research and monitoring related to the restoration project.